The areas under investigation range from the assembly of novel oligometallic arrays to the use of cobalt, palladium, and nickel in the construction of complex organic molecules.įor example, his group has developed ways to attach cyclopentadienylmetal units repeatedly to other p-ligands, such as cyclopentadienyl itself. Professor Vollhardt and his coworkers are interested in the application of transition metals to organic synthesis. 37, 497–505.Organic and Organometallic Chemistry - Transition metals and novel synthetic methodology enable the synthesis of complex natural and unnatural products. Sbai, F., Dakir, M., Auhmani, A., El Jamili, H., Akssira, M., Benharref, A., Kenz, A.Oukhrib, A., Benharref, A., Saadi, M., Berraho, M.Chiaroni, A., Riche, C., Benharref, A., Lassaba, E.

Chiaroni, A., Riche, C., Benharref, A., El Jamili, H.

Chiaroni, A., Riche, C., Benharref, A., Chekroun, A.Oak Ridge National Laboratory, Tennessee, USA. Bimoussa, A., Auhmani, A., Ait Itto, M.Benharref, A., El Ammari, L., Avignant, D., Oudahmane, A.L., Giacovazzo, C., Guagliardi, A., Moliterni, A. Agilent Technologies Ltd, Abingdon, England. An X-ray structure analysis hasĪllowed us to determine unambiguously its stereochemistry and deduce theĪbsolute configuration of its oily precursor γ-Epoxyhimachalene 1. The structure of the newly prepared 2 (scheme 2) has been establishedįrom its 1H and 13C NMR spectral data. Transform it into a solid derivative by cycloaddition reaction of aĭihalocarbene on the remaining cyclohexenic double bond. Sesquiterpene γ-himachalene without crystallographic evidence of itsĪbsolute configuration as the product was oily. Synthetise γ-Epoxyhimachalene 1 (scheme 1) from naturally occurred In the aim of preparing new epoxides from natural products, we recently Widespread occurrence, biological and synthetic utilities, the synthesis of Besides, many natural products possess thisĪs an essential structural moiety for their biological activities (Yang, Thus, epoxidesĪre important precursors in the synthesis of Antifungal products (Taylor etĪl., 1991) and different pheromones (Mori, 1989,Īl., 1997).

Epoxides are valuable intermediates frequently used as versatile buildingīlocks in organic synthesis (Qu et al., 2009).

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